Let’s say you go to your annual physical, and the doctor wants you to get a blood sample. No problem, right? It’s easy to take care of here on Earth, but if we end up living among the stars someday in deep space, this might end up being a pretty difficult task to complete. We need to understand how the environment in space can change and affect our health, so luckily, NASA is working on a new project that could get us some answers – and 3D printing will play an important part.

If we can figure out how genes affect disease and aging, and how bacteria will affect the health of astronauts, we’ll be one step closer to safe, long-term missions into outer space. Over the next four years, NASA will work to develop 3D printable designs for tools and instruments on the International Space Station (ISS) that are able to handle liquids, like blood, in microgravity without spilling; this will enable astronauts to analyze important biological samples in space.

The organization will be developing technology that can be used in the fields of microbiology important to human health known as omics – this includes research relating to proteomes, microbiomes, and genomes. NASA’s Jet Propulsion Laboratory (JPL) in California, managed for NASA by Caltech, is leading the important Omics in Space project, which was funded by the Translational Research Institute for Space Health.

NASA Extreme Environment Mission Operations (NEEMO) crew member, Matthias Maurer of ESA, works on inserting samples into the MinION DNA sequencer as part of the Biomolecule Sequencer experiment. [Image: NASA]

NASA isn’t new to studying omics, and according to the results of previous omics research, the immune systems of astronauts are weaker after living on the ISS, though scientists aren’t sure of the reason yet.

As the astronauts on the ISS can’t process biological samples on board, they have to send them down to Earth, which obviously takes some time. In addition, handling fluids in microgravity is no walk in the park for astronauts, who have to collect many samples, like their own blood and saliva, and microbes, carried by both humans and cargo, which accumulate on the ISS walls. Results could be compromised if there’s a lack of proper tools, which could lead to samples floating, forming air bubbles, or spilling – having debris floating around the ISS can be a big problem.

An automated DNA extractor designed by AI Biosciences. Omics in Space will modify the plastic cartridge so it can be 3D printed on the ISS. [Image: AI Biosciences]

“You don’t have overnight mail when you go to space. You have to do all the analysis by yourself,” explained JPL’s Kasthuri Venkateswaran, the principal investigator for Omics in Space. “This project will develop an automated system for studying molecular biology with minimal crew intervention.”

We’ve seen 3D printed medical supplies in space, but NASA astronauts hit a major milestone when they successfully sequenced DNA in space for the first time last year, using a tiny, handheld sequencing tool, developed by Oxford Nanopore Technologies, called the MinION.

Now, the Omics in Space project will take the next step and develop an automated DNA/RNA extractor, which will prepare samples for a MinION device. The extractor requires a critical cartridge in order to extract nucleic acids from the samples for the MinION sequencing, which Omics in Space is modifying so it can be 3D printed out of plastic.

Camilla Urbaniak, a post-doctoral researcher at JPL and co-investigator on the Omics in Space project, said all of the technology for the project has already been successfully tested on Earth.

“We’re taking what’s on Earth to analyze DNA and consolidating all the steps into an automated system. What’s new is we’re developing a one-stop-shop that can extract and process all of these samples,” Urbaniak explained.

A plastic cartridge design that will be 3D printable as part of Omics in Space. [Image: AI Biosciences]

This automated system would not be possible without the cartridge, which can 3D printed aboard the ISS and contains multiple wells that will hold solutions which DNA samples are dipped into. The solutions will then be mixed with magnetic particles to help purify the sample, before it’s inserted into the MinION device.

The Omics in Space project will also study the microbes that accumulate on spacecraft, so they can learn to detect genetic markers that show whether they are helpful or harmful.

This project is crucial to gaining a better understanding of human health in space, so we can help keep our astronauts safe…and one day, maybe even the population of our world as we travel into deep space.

Discuss this and other 3D printing topics at 3DPrintBoard.com or share your thoughts in the Facebook comments below. 

[Source: NASA]

 

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